Select an Option

2008 Meeting

Summary

Agenda

Presentations

Abstracts

Photos

Directions

Target Validation Session

Biodefense Proteomics Research Centers
Fifth Programmatic Meeting
Hilton Washington DC/Rockville Executive Meeting Center
Rockville, Maryland
Monday, June 9, 2008
2:00 p.m. - 5:00 p.m.

Moderators: Andras Fiser and Kami Kim -- Einstein PRC

Definition of Terms

• Target — An isolatable metabolite specific to a particular cellular pathway and/or any organism-specific protein.
• Validation — A process of quality control by which target(s) are deemed worthy of further scientific investigation.

Session Objectives

• To present progress on the various aspects of target validation.
• To have each PRC present at least one talk on their specific findings.
• To have all PRCs participate in all three breakout sessions roundtable discussions.

Breakout Sessions — Each breakout session will have two presentations and a roundtable discussion which is open to all meeting participants. It is acknowledged that these breakout sessions represent artificial divisions because there is considerable overlap between the three topics.

Opening Remarks — Moderator

1. High throughput experimental target validation
1. Scripps/FSPS - SARS CoV protein target identification/characterization as a form of validation (20-25 minutes)
2. Harvard/Myriad - High throughput experimental target validation at the Harvard and Myriad PRCs (25-30 minutes)
3. Discussion (10-15 minutes)
   5 minute break
2. High throughput computational target validation - data integration
1. PNNL - Utilization of high-throughput MS-based proteomics in conjunction with ordered experimental design to 'validate' putative drug targets (20-25 minutes)
2. Einstein - Computational approaches to target validation in Toxoplasma gondii (20-25 minutes)
3. Discussion (10-15 minutes)
   5 minute break
3. Highlights - specific drug targets identified
1. Caprion - Host phagosome target discovery and early validation (20-25 minutes)
2. Michigan - Highlights of Specific Targets Identified for Anthrax (20-25 minutes)
3. Discussion (10-15 minutes)

Concluding Remarks — Moderator