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Caprion Proteomics Inc. (Caprion)
Biodefense Proteomics Research Center at Albert Einstein College of Medicine (Einstein)
The Harvard Institute of Proteomics (HIP)
Myriad Genetics, Inc. (Myriad)
Pacific Northwest National Laboratory (PNNL)
About the Pacific Northwest National Laboratory
Dr. Richard Smith, PI
"Identifying Targets for Therapeutic Interventions Using Proteomics Technology"
A key attribute of the Pacific Northwest National Laboratory/Oregon Health & Science University (PNNL/OHSU) Biodefense Proteomics Research Center is the solid technical foundation in advanced proteomics technologies already established in the Environmental Molecular Sciences Laboratory (EMSL) at PNNL. PNNL/OHSU research efforts benefit from a large suite of cutting-edge instrumentation and data processing capabilities, as well as an established cross-disciplinary team of scientists. Additional benefits include the existing collaborative infrastructures at OHSU and PNNL that provide extensive support for major instrumentation and baseline operational costs.
For more information regarding work taking place at PNNL, see our November 2005 newsletter. See the Biodefense Proteomics Catalog for PNNL's publicly available proteomic data.
[ click on a link above for further information or here to see page in full ]
Goals and Objectives
- Develop mass and time tag databases for Salmonella typhimurium and Salmonella typhi organisms
- Perform mass and time tag for vaccinia virus and monkeypox
- Confirm virus handling and preparation function for orthopox viruses
- Continue designing orthopox experiments based on testable hypotheses
- Characterize S. typhimurium (strains LT2 and 14028) and S. typhi (strain TY2) proteomes
- AMT tag analysis of regulatory mutants
- Methods development for growth in host cells
- Use results to design further experiments
Presentations
- Evolving Capabilities and Asking Tougher Questions
Dick Smith [5/30/07, PDF, 14 pages/12.08MB]
- Orthopoxvirus Proteomics
Scott Wong [5/30/07, PPT, 24 slides/2.38MB]
- Regulation of Virulence in Salmonella and How This Can Be Used to Identify Therapeutic Targets
Fred Heffron [5/30/07, PPT, 25 slides/3MB]
- Towards a Proteomics Data Resources with Emphasis on Therapeutic Targets [3/6/07, PDF, 17 pages/1.95MB]
Publications
- Proteomics analysis of the causative agent of typhoid fever (Subscription required to view full article) | Abstract
Ansong C, Yoon H, Norbeck AD, Gustin JK, McDermott JE, Mottaz HM, Rue J, Adkins JN, Heffron F, Smith RD.
Bioinformatics 2007 Aug 1;23(15):2021-3 - PMID: 18166006
- VIPER: an advanced software package to support high-throughput LC-MS peptide identification (Subscription required to view full article) | Abstract
Monroe ME, Tolic N, Jaitly N, Shaw JL, Adkins JN, Smith RD.
Bioinformatics 2007 Aug 1;23(15):2021-3 - PMID: 17545182
- PQuad - a visual analysis platform for proteomic data exploration of microbial organisms (Subscription required to view full article) | Abstract
Webb-Robertson BJ, Peterson ES, Singhal M, Klicker KR, Oehmen CS, Adkins JN, Havre SL.
Bioinformatics 2007 Jul 1;23(13):1705-7 - PMID: 17483503
- Targeted protein degradation by Salmonella under phagosome-mimicking culture conditions investigated using comparative peptidomics (Subscription required to view full article) | Abstract | Supplemental Data
Manes NP, Gustin JK, Rue J, Mottaz HM, Purvine SO, Norbeck AD, Monroe ME, Zimmer JS, Metz TO, Adkins, JN, Smith RD, and Heffron F.
Mol Cell Proteomics 2007 Apr;6(4):717-27 - PMID: 17228056
- MicroSPE-nanoLC-ESI-MS/MS using 10-microm-i.d. silica-based monolithic columns for proteomics (Registration required to view full article) | Abstract
Luo Q, Page JS, Tang K, Smith RD.
Anal Chem. 2007 Jan 15;79(2):540-5 - PMID: 17222018
Key Players |
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| Richard D. Smith, Ph.D. (Principal Investigator) Pacific Northwest National Laboratory Joshua Adkins, Ph.D. (IWG member) Kenneth Auberry, Ph.D. (IWG member) |
Fred Heffron, Ph.D. Program in Molecular and Cellular Biosciences Scott Wong, Ph.D. |
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