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Brucella abortus
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Description A small aerobic, fastidious, gram-negative coccobacilli which requires the addition of CO2 for its growth. B. abortus is one in a complex pattern of strains which infect and have reservoirs in animals. Cows are the primary source for B. abortus with B. melitensis from goats, B. suis from pigs and B. canis from dogs. Infection with the bacteria causes Brucellosis, a disease condition marked by inconstant fevers, sweating, weakness, anorexia, headaches, depression and muscular and bodily pain. These symptoms usually arise in one to three weeks and persist for anywhere from a few weeks to many months or even years. Significance in Biodefense Proteomics Brucellae are considered Category B select agents with potential for use in bioterrorism. The bacteria are inexpensive to produce and disperse and have a low human infectious dose. Transmission can occur through several routes — respiratory mucosa, conjunctivae, gastrointestinal tract and abraded skin or open wound. Infection results in prolonged illness with long-term sequelae although person-to-person transmission does not occur. The mechanism of pathogenesis of Brucella infection is not completely known in its natural host species or in humans. However, once inside the body, the bacteria are ingested by phagocytes where they are able to escape cell death by inhibition of the fusion of lysosome to phagosome. This type of subversion of normal cellular processes it seen in other Category A or B microbes, so this |
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| relatively less virulent bacteria is being studied to illuminate all microbes that behave in this manner. | ||
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| Organism | PRC | Data Type | Pathogen or Host Data Sets |
SOPs | Master Protein Directory | Pathogen Specific Publications |
Reagents | Complete Predicted Proteome |
| Brucella abortus |
| 3077 |
Key to Catalog Links
| Organism = view detailed information about the selected organism PRC = view information about the Proteomics Research Centers Pathogen or Host Data Sets = view data sets/experimental details for pathogen and host SOPs = view or download related experiment Standard Operating Procedures |
Master Protein Directory = view all identified pathogen and host proteins Pathogen Specific Publications = view abstracts, manuscripts and/or publications Reagents = request reagents by ID from BEI, PFGRC or PlasmID Complete Predicted Proteome= view complete predicted proteomes |
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