The human brain acetylome reveals that decreased

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proteomicsresource

The human mind acetylome reveals that decreased acetylation of mitochondrial proteins associates with Alzheimer’s illness

 

Metabolic modifications that correlate to cognitive modifications are well-known in AD. Metabolism is usually linked to useful modifications in proteins by post-translational modifications. The significance of the regulation of transcription by acetylation is properly documented. Superior mass spectrometry reveals lots of of acetylated proteins in a number of tissues, however the acetylome of human mind, its useful significance and the modifications with illness are unknown. Filling this hole is important for understanding the pathophysiology and improvement of therapies.

To fill this hole, we assessed the human mind acetylome in human mind and its modifications with Alzheimer’s Illness (AD). Greater than 5% of the 4,442 proteins from the human mind world proteome had been acetylated. Acetylated proteins had been primarily discovered within the cytosol (148), mitochondria (100), nucleus (91) and plasma membrane (58).

The comparability of the mind acetylome in controls to that of sufferers with AD revealed hanging and selective variations by way of its abundances of acetylated peptides/websites. Acetylation of 18 mitochondrial proteins decreased, whereas acetylation of two cytosolic proteins, tau and GFAP, elevated. Our experiments exhibit that acetylation at some particular lysine websites alters enzyme operate. The outcomes point out that basic activation of de-acetylases (i.e., sirtuins) just isn’t an applicable therapeutic method for AD.

proteomicsresource
proteomicsresource

Monoclonal IgG (Immunoglobulin Gamma Heavy Chain) (B Cell Marker) Antibody - Without BSA and Azide, Clone: SPM556

AMM00286G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human IgG (Immunoglobulin Gamma Heavy Chain) (B Cell Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone SPM556. This antibody is applicable in IHC-P, IF, FC

Monoclonal IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) Antibody - Without BSA and Azide, Clone: IM260

AMM00291G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone IM260. This antibody is applicable in WB and IHC-P, IF, FC

Monoclonal IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) Antibody - Without BSA and Azide, Clone: SPM557

AMM00293G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone SPM557. This antibody is applicable in WB and IHC-P, IF, FC

Monoclonal IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) Antibody - Without BSA and Azide, Clone: IM373

AMM00294G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone IM373. This antibody is applicable in WB and IHC-P, IF, FC

Monoclonal IgA (Immunoglobulin Alpha Heavy Chain) (B-Cell Marker) Antibody - Without BSA and Azide, Clone: IA761

AMM00886G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human IgA (Immunoglobulin Alpha Heavy Chain) (B-Cell Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone IA761. This antibody is applicable in IHC, IF, FC

Monoclonal IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) Antibody - Without BSA and Azide, Clone: SPM188

AMM00899G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone SPM188. This antibody is applicable in IHC, IF, FC

Monoclonal IgG (Immunoglobulin Gamma Heavy Chain) (B-Cell Marker) Antibody - Without BSA and Azide, Clone: ICO-97

AMM00289G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human IgG (Immunoglobulin Gamma Heavy Chain) (B-Cell Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone ICO-97. This antibody is applicable in IF, FC

Monoclonal IgG (Immunoglobulin Gamma Heavy Chain) (B-Cell Marker) Antibody - Without BSA and Azide, Clone: B33/20

AMM00893G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human IgG (Immunoglobulin Gamma Heavy Chain) (B-Cell Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone B33/20. This antibody is applicable in IHC-P, IF, FC

Monoclonal IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) Antibody - Without BSA and Azide, Clone: ICO-30

AMM00896G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone ICO-30. This antibody is applicable in IHC, IF, FC

Monoclonal IgA (Immunoglobulin Alpha Heavy Chain) (B-Cell Marker) Antibody - Without BSA and Azide, Clone: HISA43

AMM00882G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human IgA (Immunoglobulin Alpha Heavy Chain) (B-Cell Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone HISA43. This antibody is applicable in IHC, IF, FC

Monoclonal IgA (Immunoglobulin Alpha Heavy Chain) (B-Cell Marker) Antibody - Without BSA and Azide, Clone: SPM187

AMM00884G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human IgA (Immunoglobulin Alpha Heavy Chain) (B-Cell Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone SPM187. This antibody is applicable in IHC, IF, FC

Monoclonal IgG (Immunoglobulin Gamma Heavy Chain) (B-Cell Marker) Antibody - Without BSA and Azide, Clone: IG217 + IG266

AMM00288G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human IgG (Immunoglobulin Gamma Heavy Chain) (B-Cell Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone IG217 + IG266. This antibody is applicable in IHC-P, IF, FC

Monoclonal IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) Antibody - Without BSA and Azide, Clone: IM260 + IM373 + ICO-30

AMM00906G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone IM260 + IM373 + ICO-30. This antibody is applicable in WB, IHC and IF, FC

Monoclonal IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) Antibody - Without BSA and Azide, Clone: DA4-4; same as SA-DA4 or HB57

AMM00290G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone DA4-4; same as SA-DA4 or HB57. This antibody is applicable in IHC-P, IF, FC

*Immunoglobulin G (IgG) Depleted Human Serum

IIGGDS100ML each
EUR 427
Description: *Immunoglobulin G (IgG) Depleted Human Serum

Goat anti-Mouse IgG(H+L) Cross absorbed against human immunoglobulins

E16SPU1011-100 100µg
EUR 286.8

Goat anti-Mouse IgG(H+L) Cross absorbed against human immunoglobulins

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Goat anti-Mouse IgG(H+L) Cross absorbed against human immunoglobulins

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EUR 411.6

Goat anti-Rabbit IgG(H+L) Cross absorbed against human immunoglobulins

E16SPU1021-100 100µg
EUR 286.8

Goat anti-Rabbit IgG(H+L) Cross absorbed against human immunoglobulins

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EUR 520.8

Goat anti-Rabbit IgG(H+L) Cross absorbed against human immunoglobulins

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EUR 411.6

Goat anti-Human IgG(H+L) Cross absorbed against mouse immunoglobulins

E16SPU1031-100 100µg
EUR 286.8

Goat anti-Human IgG(H+L) Cross absorbed against mouse immunoglobulins

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EUR 520.8

Goat anti-Human IgG(H+L) Cross absorbed against mouse immunoglobulins

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Rabbit anti-Rat IgG(H+L) Cross absorbed against mouse immunoglobulins

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Rabbit anti-Rat IgG(H+L) Cross absorbed against mouse immunoglobulins

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Rabbit anti-Rat IgG(H+L) Cross absorbed against mouse immunoglobulins

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Goat anti-Mouse IgG(H+L), Cross absorbed against human immunoglobulins, HRPO

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EUR 286.8

Goat anti-Mouse IgG(H+L), Cross absorbed against human immunoglobulins, HRPO

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EUR 520.8

Goat anti-Mouse IgG(H+L), Cross absorbed against human immunoglobulins, HRPO

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EUR 411.6

Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulins, HRPO

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EUR 286.8

Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulins, HRPO

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EUR 520.8

Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulins, HRPO

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EUR 411.6

Goat anti-Human IgG(H+L), Cross absorbed against mouse immunoglobulins, HRPO

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EUR 286.8

Goat anti-Human IgG(H+L), Cross absorbed against mouse immunoglobulins, HRPO

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Goat anti-Human IgG(H+L), Cross absorbed against mouse immunoglobulins, HRPO

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EUR 411.6

Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulins, Biotin

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EUR 286.8

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EUR 520.8

Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulins, Biotin

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EUR 411.6

Goat anti-Human IgG(H+L), Cross absorbed against mouse immunoglobulins, Biotin

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EUR 286.8

Goat anti-Human IgG(H+L), Cross absorbed against mouse immunoglobulins, Biotin

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Goat anti-Human IgG(H+L), Cross absorbed against mouse immunoglobulins, Biotin

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EUR 411.6

Pig Platelet Associated Immunoglobulins (PAIg) ELISA Kit

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EUR 990

Goat anti-Mouse IgG(H+L) Cross absorbed against human and rat immunoglobulins

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EUR 286.8

Goat anti-Mouse IgG(H+L) Cross absorbed against human and rat immunoglobulins

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EUR 520.8

Goat anti-Mouse IgG(H+L) Cross absorbed against human and rat immunoglobulins

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EUR 411.6

Goat anti-Mouse IgG(H+L), Cross absorbed against human immunoglobulins, Purified

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EUR 286.8

Goat anti-Mouse IgG(H+L), Cross absorbed against human immunoglobulins, Purified

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EUR 520.8

Goat anti-Mouse IgG(H+L), Cross absorbed against human immunoglobulins, Purified

E16PU1011-500 500 ug
EUR 411.6

Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulins, Purified

E16PU1021-100 100 ug
EUR 286.8

Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulins, Purified

E16PU1021-1000 1000 ug
EUR 520.8

Goat anti-Rabbit IgG(H+L), Cross absorbed against human immunoglobulins, Purified

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EUR 411.6

Goat anti-Human IgG(H+L), Cross absorbed against mouse immunoglobulins, Purified

E16PU1031-100 100 ug
EUR 286.8

Goat anti-Human IgG(H+L), Cross absorbed against mouse immunoglobulins, Purified

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EUR 520.8

Goat anti-Human IgG(H+L), Cross absorbed against mouse immunoglobulins, Purified

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EUR 411.6

Sheep Platelet Associated Immunoglobulins (PAIg) ELISA Kit

abx364426-96tests 96 tests
EUR 1111.2

Goat anti-Mouse IgG(H+L) Cross absorbed against human and rabbit immunoglobulins

E16SPU1012-100 100µg
EUR 286.8

Goat anti-Mouse IgG(H+L) Cross absorbed against human and rabbit immunoglobulins

E16SPU1012-1000 1000µg
EUR 520.8

Goat anti-Mouse IgG(H+L) Cross absorbed against human and rabbit immunoglobulins

E16SPU1012-500 500µg
EUR 411.6

Goat anti-Rabbit IgG(H+L) Cross absorbed against human and mouse immunoglobulins

E16SPU1022-100 100µg
EUR 286.8

Goat anti-Rabbit IgG(H+L) Cross absorbed against human and mouse immunoglobulins

E16SPU1022-1000 1000µg
EUR 520.8

Goat anti-Rabbit IgG(H+L) Cross absorbed against human and mouse immunoglobulins

E16SPU1022-500 500µg
EUR 411.6

Rabbit Platelet Associated Immunoglobulins (PAIg) ELISA Kit

abx362488-96tests 96 tests
EUR 990

Monkey Platelet Associated Immunoglobulins (PAIg) ELISA Kit

abx359730-96tests 96 tests
EUR 990

Human platelet-associated immunoglobulins,PAIg ELISA Kit

201-12-0183 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Chicken Platelet Associated Immunoglobulins (PAIg) ELISA Kit

abx356467-96tests 96 tests
EUR 990

Human platelet-associated immunoglobulins,PAIg ELISA Kit

CN-04091H1 96T
EUR 556.8

Human platelet-associated immunoglobulins,PAIg ELISA Kit

CN-04091H2 48T
EUR 375.6

Human platelet-associated immunoglobulins(PAIg)ELISA Kit

GA-E0199HM-48T 48T
EUR 346.8

Human platelet-associated immunoglobulins(PAIg)ELISA Kit

GA-E0199HM-96T 96T
EUR 559.2

Human platelet-associated immunoglobulins(PAIg)ELISA Kit

QY-E00610 96T
EUR 433.2

Human platelet-associated immunoglobulins,PAIg ELISA Kit

YLA2110HU-48T 48T
EUR 435

Human platelet-associated immunoglobulins,PAIg ELISA Kit

YLA2110HU-96T 96T
EUR 562.5

Human platelet-associated immunoglobulins,PAIg ELISA Kit

SL1421Hu 96 Tests
EUR 468

Goat anti-Mouse IgG(H+L), Cross absorbed against human and rat immunoglobulins, HRPO

E16PH1013-100 100 ul
EUR 286.8

Goat anti-Mouse IgG(H+L), Cross absorbed against human and rat immunoglobulins, HRPO

E16PH1013-1000 1000 ul
EUR 520.8

Goat anti-Mouse IgG(H+L), Cross absorbed against human and rat immunoglobulins, HRPO

E16PH1013-500 500 ul
EUR 411.6

Goat anti-Mouse IgG(H+L), Cross absorbed against human and rat immunoglobulins, Biotin

E16PB1013-100 100 ul
EUR 286.8

Goat anti-Mouse IgG(H+L), Cross absorbed against human and rat immunoglobulins, Biotin

E16PB1013-1000 1000 ul
EUR 520.8

Goat anti-Mouse IgG(H+L), Cross absorbed against human and rat immunoglobulins, Biotin

E16PB1013-500 500 ul
EUR 411.6

Goat anti-Mouse IgG(H+L), Cross absorbed against human and rabbit immunoglobulins, HRPO

E16PH1012-100 100 ul
EUR 286.8

Goat anti-Mouse IgG(H+L), Cross absorbed against human and rabbit immunoglobulins, HRPO

E16PH1012-1000 1000 ul
EUR 520.8

Goat anti-Mouse IgG(H+L), Cross absorbed against human and rabbit immunoglobulins, HRPO

E16PH1012-500 500 ul
EUR 411.6

Goat anti-Rabbit IgG(H+L), Cross absorbed against human and mouse immunoglobulins, HRPO

E16PH1022-100 100 ul
EUR 286.8

Goat anti-Rabbit IgG(H+L), Cross absorbed against human and mouse immunoglobulins, HRPO

E16PH1022-1000 1000 ul
EUR 520.8

Goat anti-Rabbit IgG(H+L), Cross absorbed against human and mouse immunoglobulins, HRPO

E16PH1022-500 500 ul
EUR 411.6

Rabbit anti-Rat IgG(H+L), Cross absorbed against human and mouse immunoglobulins, HRPO

E16PH2011-100 100 ul
EUR 286.8

Rabbit anti-Rat IgG(H+L), Cross absorbed against human and mouse immunoglobulins, HRPO

E16PH2011-1000 1000 ul
EUR 520.8

Rabbit anti-Rat IgG(H+L), Cross absorbed against human and mouse immunoglobulins, HRPO

E16PH2011-500 500 ul
EUR 411.6

Guinea pig Platelet Associated Immunoglobulins (PAIg) ELISA Kit

abx357670-96tests 96 tests
EUR 990

Goat anti-Mouse IgG(H+L), Cross absorbed against human and rabbit immunoglobulins, Biotin

E16PB1012-100 100 ul
EUR 286.8

Goat anti-Mouse IgG(H+L), Cross absorbed against human and rabbit immunoglobulins, Biotin

E16PB1012-1000 1000 ul
EUR 520.8

Goat anti-Mouse IgG(H+L), Cross absorbed against human and rabbit immunoglobulins, Biotin

E16PB1012-500 500 ul
EUR 411.6

Goat anti-Rabbit IgG(H+L), Cross absorbed against human and mouse immunoglobulins, Biotin

E16PB1022-100 100 ul
EUR 286.8

Goat anti-Rabbit IgG(H+L), Cross absorbed against human and mouse immunoglobulins, Biotin

E16PB1022-1000 1000 ul
EUR 520.8

Goat anti-Rabbit IgG(H+L), Cross absorbed against human and mouse immunoglobulins, Biotin

E16PB1022-500 500 ul
EUR 411.6

Rabbit anti-Rat IgG(H+L), Cross absorbed against human and mouse immunoglobulins, Biotin

E16PB2011-100 100 ul
EUR 286.8

Rabbit anti-Rat IgG(H+L), Cross absorbed against human and mouse immunoglobulins, Biotin

E16PB2011-1000 1000 ul
EUR 520.8

Rabbit anti-Rat IgG(H+L), Cross absorbed against human and mouse immunoglobulins, Biotin

E16PB2011-500 500 ul
EUR 411.6

Goat anti-Mouse IgG(H+L), Cross absorbed against human and rat immunoglobulins, Purified

E16PU1013-100 100 ug
EUR 286.8

Goat anti-Mouse IgG(H+L), Cross absorbed against human and rat immunoglobulins, Purified

E16PU1013-1000 1000 ug
EUR 520.8

Goat anti-Mouse IgG(H+L), Cross absorbed against human and rat immunoglobulins, Purified

E16PU1013-500 500 ug
EUR 411.6

Goat anti-Mouse IgG(H+L), Cross absorbed against human and rabbit immunoglobulins, Purified

E16PU1012-100 100 ug
EUR 286.8

Goat anti-Mouse IgG(H+L), Cross absorbed against human and rabbit immunoglobulins, Purified

E16PU1012-1000 1000 ug
EUR 520.8

Goat anti-Mouse IgG(H+L), Cross absorbed against human and rabbit immunoglobulins, Purified

E16PU1012-500 500 ug
EUR 411.6

Goat anti-Rabbit IgG(H+L), Cross absorbed against human and mouse immunoglobulins, Purified

E16PU1022-100 100 ug
EUR 286.8

Goat anti-Rabbit IgG(H+L), Cross absorbed against human and mouse immunoglobulins, Purified

E16PU1022-1000 1000 ug
EUR 520.8

Goat anti-Rabbit IgG(H+L), Cross absorbed against human and mouse immunoglobulins, Purified

E16PU1022-500 500 ug
EUR 411.6

Rabbit anti-Rat IgG(H+L), Cross absorbed against human and mouse immunoglobulins, Purified

E16PU2011-100 100 ug
EUR 286.8

Rabbit anti-Rat IgG(H+L), Cross absorbed against human and mouse immunoglobulins, Purified

E16PU2011-1000 1000 ug
EUR 520.8

Rabbit anti-Rat IgG(H+L), Cross absorbed against human and mouse immunoglobulins, Purified

E16PU2011-500 500 ug
EUR 411.6

anti- immunoglobulin kappa antibody

FNab04295 100µg
EUR 658.5
Description: Antibody raised against immunoglobulin kappa

Anti-hRRP4 Immunoglobulin antibody

STJ16100944 100 µg
EUR 1070.4

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (TIE1) Antibody

abx238689-100ug 100 ug
EUR 610.8

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (TIE1) Antibody

abx218984-100ug 100 ug
EUR 526.8

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (TIE1) Antibody

abx224054-100ug 100 ug
EUR 493.2

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Antibody

20-abx175006
  • EUR 844.80
  • EUR 427.20
  • 1 mg
  • 200 ug

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Antibody

20-abx175007
  • EUR 393.60
  • EUR 994.80
  • EUR 526.80
  • EUR 184.80
  • EUR 309.60
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Antibody

20-abx178787
  • EUR 1362.00
  • EUR 661.20
  • 1 mg
  • 200 ug

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Antibody

20-abx178788
  • EUR 1412.40
  • EUR 693.60
  • 1 mg
  • 200 ug

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Antibody

20-abx178789
  • EUR 1545.60
  • EUR 744.00
  • 1 mg
  • 200 ug

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Antibody

20-abx178790
  • EUR 1796.40
  • EUR 844.80
  • 1 mg
  • 200 ug

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (TIE1) Antibody

20-abx116389
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (TIE1) Antibody

abx016112-100ug 100 ug
EUR 493.2

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (TIE1) Antibody

abx019188-100ug 100 ug
EUR 410.4

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (TIE1) Antibody

abx033614-400ul 400 ul
EUR 627.6

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (TIE1) Antibody

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EUR 343.2

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Antibody

20-abx128493
  • EUR 376.80
  • EUR 159.60
  • EUR 994.80
  • EUR 510.00
  • EUR 326.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Antibody

20-abx128893
  • EUR 376.80
  • EUR 159.60
  • EUR 994.80
  • EUR 510.00
  • EUR 326.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Antibody

20-abx129388
  • EUR 493.20
  • EUR 159.60
  • EUR 1362.00
  • EUR 661.20
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (TIE1) Antibody

20-abx008633
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (TIE1) Antibody

20-abx014966
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Anti-hRPP20 Immunoglobulin antibody

STJ16100943 100 µg
EUR 1070.4

Immunoglobulin Binding Protein 1 (IGBP1) Antibody

abx234166-100ug 100 ug
EUR 577.2

Immunoglobulin Binding Protein 1 (IGBP1) Antibody

abx234167-100ug 100 ug
EUR 610.8

Immunoglobulin Binding Protein 1 (IGBP1) Antibody

20-abx172867
  • EUR 1028.40
  • EUR 526.80
  • 1 mg
  • 200 ug

Immunoglobulin Binding Protein 1 (IGBP1) Antibody

20-abx176905
  • EUR 1446.00
  • EUR 693.60
  • 1 mg
  • 200 ug

Immunoglobulin Binding Protein 1 (IGBP1) Antibody

20-abx176906
  • EUR 1696.80
  • EUR 794.40
  • 1 mg
  • 200 ug

Immunoglobulin Binding Protein 1 (IGBP1) Antibody

20-abx113109
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Immunoglobulin Binding Protein 1 (IGBP1) Antibody

abx028675-400ul 400 ul
EUR 627.6

Immunoglobulin Binding Protein 1 (IGBP1) Antibody

abx028675-80l 80 µl
EUR 343.2

Immunoglobulin Binding Protein 1 (IGBP1) Antibody

20-abx125981
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

immunoglobulin Kappa (immunoglobulin kappa) Antibody

abx234295-100ug 100 ug
EUR 610.8

Anti-Human Immunoglobulin IgA antibody

STJ16100584 1 mL
EUR 636

Anti-Human Immunoglobulin IgE antibody

STJ16100585 1 mL
EUR 636

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Polyclonal Antibody (Human)

4-PAA125Hu01
  • EUR 231.60
  • EUR 1998.00
  • EUR 519.60
  • EUR 279.60
  • EUR 229.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1)

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Polyclonal Antibody (Human)

4-PAA125Hu02
  • EUR 231.60
  • EUR 1998.00
  • EUR 519.60
  • EUR 279.60
  • EUR 229.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1)

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Polyclonal Antibody (Mouse)

4-PAA125Mu01
  • EUR 283.20
  • EUR 2805.60
  • EUR 703.20
  • EUR 352.80
  • EUR 250.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1)

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Polyclonal Antibody (Human), PE

4-PAA125Hu01-PE
  • EUR 277.20
  • EUR 2061.60
  • EUR 622.80
  • EUR 334.80
  • EUR 201.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1). This antibody is labeled with PE.

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Polyclonal Antibody (Human), PE

4-PAA125Hu02-PE
  • EUR 277.20
  • EUR 2061.60
  • EUR 622.80
  • EUR 334.80
  • EUR 201.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1). This antibody is labeled with PE.

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Polyclonal Antibody (Mouse), PE

4-PAA125Mu01-PE
  • EUR 339.60
  • EUR 2942.40
  • EUR 843.60
  • EUR 423.60
  • EUR 226.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1). This antibody is labeled with PE.

Immunoglobulin (IG) Antibody

abx024071-200ug 200 ug
EUR 1011.6

Immunoglobulin M Antibody

E40M619 50ul
EUR 395
Description: Available in various conjugation types.

immunoglobulin G Antibody

E40M620 50ul
EUR 395
Description: Available in various conjugation types.

Immunoglobulin M (IgM) Antibody

abx139088-01mg 0.1 mg
EUR 376.8

Immunoglobulin G (IgG) Antibody

20-abx104924
  • EUR 526.80
  • EUR 159.60
  • EUR 1479.60
  • EUR 710.40
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Immunoglobulin G (IgG) Antibody

20-abx104928
  • EUR 526.80
  • EUR 159.60
  • EUR 1479.60
  • EUR 710.40
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Immunoglobulin D (IgD) Antibody

20-abx172868
  • EUR 978.00
  • EUR 510.00
  • 1 mg
  • 200 ug

Immunoglobulin E (IgE) Antibody

20-abx172869
  • EUR 944.40
  • EUR 493.20
  • 1 mg
  • 200 ug

Immunoglobulin E (IgE) Antibody

20-abx172870
  • EUR 1011.60
  • EUR 526.80
  • 1 mg
  • 200 ug

Immunoglobulin E (IgE) Antibody

20-abx172871
  • EUR 427.20
  • EUR 1095.60
  • EUR 560.40
  • EUR 184.80
  • EUR 326.40
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Immunoglobulin G (IgG) Antibody

20-abx172872
  • EUR 844.80
  • EUR 427.20
  • 1 mg
  • 200 ug

Variable-Temperature Electrospray Ionization for Temperature-Dependent Folding/Refolding Reactions of Proteins and Ligand Binding

 

Stabilities and construction(s) of proteins are immediately coupled to their native atmosphere or Gibbs free vitality panorama as outlined by solvent, temperature, stress, and focus. Resolution pH, ionic energy, cofactors, chemical chaperones, and osmolytes perturb the chemical potential and induce additional modifications in construction, stability, and performance.

At current, no single analytical method can monitor these results in a single measurement. Mass spectrometry and ion mobility-mass spectrometry play more and more important roles in research of proteins, protein complexes, and even membrane protein complexes; nevertheless, with few exceptions, the results of the answer temperature on the soundness and construction(s) of analytes haven’t been completely investigated.

Right here, we describe a brand new variable-temperature electrospray ionization (vT-ESI) supply that makes use of a thermoelectric chip to chill and warmth the answer contained throughout the static ESI emitter. This design permits for resolution temperatures to be various from 5 to 98 °C with brief equilibration instances (<2 min) between exactly managed temperature modifications.

The efficiency of the equipment for vT-ESI-mass spectrometry and vT-ESI-ion mobility-mass spectrometry research of cold- and heat-folding reactions is demonstrated utilizing ubiquitin and frataxin. Instrument efficiency for research on temperature-dependent ligand binding is proven utilizing the chaperonin GroEL.

 

Overexpression of centromere protein Ok (CENPK) gene in Differentiated Thyroid Carcinoma promote cell Proliferation and Migration

 

  • Differentiated thyroid carcinoma (DTC) is among the most typical malignant tumors. Growing proof signifies that centromere protein Ok(CENPK) could play a key position in selling carcinogenesis. The expression, organic capabilities, and scientific significance of CENPK in DTC are nonetheless unclear. The CENPK expression within the DTC specimen was confirmed utilizing quantitative real-time PCR and Western blot.
  • The expression of CENPK was silenced and promoted by lentivirus-mediated transfection with shRNA sequences or CENPK plasmid focusing on CENPK in TPC1 and FTC-133 cells, respectively. Colony formation, Cell Counting Package-8 (CCK-8), Transwell invasion, and scratch assays had been carried out to evaluate the malignant organic properties of FTC-133 and TPC1 cells.
  • Tumorigenicity assay was carried out utilizing C57BL/6 mice to discover the affect of CENPK on the expansion of TPC1. The current work advised that the expression of CENPK remarkably elevated in follicular thyroid most cancers and papillary thyroid most cancers tissue samples on the mRNA degree. Immunohistochemical staining additionally confirmed constant outcomes on the protein degree. As well as, CENPK mRNA expression degree confirmed nice worth in prognosis of DTC.
  • Knockdown of CENPK considerably inhibited the invasion and migration of TPC1 and FTC-133 cells. In distinction, CENPK overexpression promoted invasion and migration of TPC1 and FTC-133 cells.
  • Knockdown and overexpression of CENPK confirmed constant impact on DTC tumor development and expression of Ki-67 invivo. Our outcomes indicated that CENPK was evidently upregulated in DTC. Pulling down CENPK suppressed TPC1 cell proliferation, invasion and migration. Focusing on the CENPK could also be anovel therapeutic methodology for DTC.

 

The Velocity of Allosteric Signaling Inside a Single-Area Protein

Whereas a lot is understood about completely different allosteric regulation mechanisms, the character of the allosteric sign and the time scale on which it propagates stays elusive. The PDZ3 area from postsynaptic density-95 protein is a small protein area with a terminal third α-helix, i.e., the α3-helix, which is understood to be allosterically energetic. By cross-linking the allosteric helix with an azobenzene moiety, we obtained a photocontrollable PDZ3 variant.

Photoswitching triggers its allosteric transition, leading to a change in binding affinity of a peptide to the distant binding pocket. Utilizing time-resolved infrared and UV/vis spectroscopy, we comply with the allosteric sign transduction and reconstruct the timeline during which the allosteric sign propagates via the protein inside 200 ns.

A New Framework for Discovering Protein Complicated and Illness Affiliation through Mining A number of Databases

 

One necessary problem within the post-genomic period is to discover illness mechanisms by effectively integrating completely different kinds of organic information. The truth is, a single illness is normally precipitated via a number of genes merchandise corresponding to protein complexes quite than single gene.

Due to this fact, it’s significant for us to uncover protein communities from the protein-protein interplay community and use them for inferring disease-disease associations. On this article, we suggest a brand new framework together with protein-protein networks, disease-gene associations and disease-complex pairs to cluster protein complexes and infer illness associations.

Complexes found by our method is superior in high quality (Sn, PPV and ACC) and clustering amount than different 4 standard strategies on three PPI networks. A scientific evaluation reveals that illness pairs sharing extra protein complexes (corresponding to Glucose and Lipid Metabolic Problems) are extra comparable and overlapping proteins could have completely different roles in numerous ailments. These findings can present scientific students and medical practitioners with new concepts on illness identification and therapy.

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